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Chloramphenicol resistance (Cmr) is primarily due to the presence of chloramphenicol acetyltransferases (CATs) which inactive chloramphenicol [10]. Cmr may also be due to the efflux of chloramphenicol via specific membrane-associated transporters [11]. Both, the genes coding for CATs and specific exporters, are often associated with mobile elements such as plasmids, transposons, or gene cassettes and are able to be transferred by conjugation, mobilization, transduction, or transformation between bacteria of different species and genera. Some chromosomal multidrug transporters have also been identified which export chloramphenicol [12]. There are two different types of CAT enzymes which are genetically unrelated (Table 15.3). Pscs7 apps.
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